Determination of Valproic Acid in Human Serum by High-Performance Liquid Chromatography with Fluorescence Detection.
نویسندگان
چکیده
منابع مشابه
Determination of valproic acid in human plasma using dispersive liquid-liquid microextraction followed by gas chromatography-flame ionization detection
Objective(s): Dispersive liquid-liquid microextraction coupled with gas chromatography (GC)-flame ionization detector was developed for the determination of valproic acid (VPA) in human plasma. Materials and Methods: Using a syringe, a mixture of suitable extraction solvent (40 µl chloroform) and disperser (1 ml acetone) was quickly added to 10 ml of diluted plasma sample containing VPA (pH, 1....
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Background: Astaxanthin is widely and naturally distributed in marine animals including, crustaceans, such as shrimp, crabs, and fish, such as salmon and trout. Methods: A total of 20 trout samples were collected from local market and were analyzed for astaxanthin via HPLC-UV. Analyte extraction was done by water, methanol, dichloromethane, and acetonitrile 4.5:85:5:45.5, v/v/v/v. Results: Desp...
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An accurate and sensitive reversed-phase high-performance liquid chromatograph-ic method for determination of sertraline in human serum is described using 4-chloro-7-nitrobenzofurazan as pre-column derivatization agent. The drug and an internal standard (azithrimycin) were extracted from serum using a mixture of diethyl ether-chloroform and subjected to the pre-column derivatization with...
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A sensitive high-performance liquid chromatographic (HPLC) method is described for the determination of posaconazole in human plasma/serum. The method is based on a single dilution step by treating the sample with methanol, and followed by the direct injection of the sample into the HPLC system. Posaconazole and internal standard ketoconazole in the methanol extract are subsequently analyzed by...
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background valproic acid is widely used as an anticonvulsant and mood-stabilizing drug in the treatment of epilepsy. determination of serum valproic acid is required in epilepsy therapy for efficient control of seizures. objectives in the present study, the gas chromatography method was applied to determine serum valproic acid and resulting data were compared with those obtained by high perform...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1999
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.22.975